Part 1 – Absolute No-Go Screening

(If you answer YES to even ONE of these, stop here. Do not use psilocybin in any dose.)

• Current or past schizophrenia, schizoaffective disorder, or psychotic episodes
• First-degree relative (parent, sibling, child) with schizophrenia or psychotic disorders
• Diagnosed bipolar I or II (especially with any manic or psychotic episodes)
• Active severe borderline personality disorder with frequent dissociation or self-harm
• Currently taking SSRIs, SNRIs, tricyclics, MAOIs, lithium, antipsychotics, tramadol, or strong 5-HT2B agonists
• Uncontrolled high blood pressure, recent heart attack, angina, or serious arrhythmia
• Pregnant or breastfeeding
• Under 21 years old
• Active addiction or <12 months sober from alcohol/hard drugs
• Currently suicidal, in acute psychosis, or in a manic episode
• Psilocybin is illegal where you live and you are unwilling/unable to comply

→ One YES = Full stop. Explore non-psychedelic options (therapy, exercise, meditation, etc.).

Part 2 – Gray-Zone Warnings

(If any apply, only proceed with direct professional/medical supervision)

• History of severe depression with psychotic features
• Epilepsy or seizure disorder
• Severe anxiety or panic disorder with frequent depersonalization/derealization
• Heavy daily cannabis, stimulant, or ketamine use
• Significant liver or kidney disease

Part 3 – Determine Your True Need

(Only continue if you cleared Part 1 completely)

Rank your primary reason for considering psilocybin (choose the one that fits best):

A – Everyday Self-Improvement & Optimization
(Usually safe to explore independently with micro/minor dosing)

• Boost creativity, focus, energy, or mood
• Build better habits, motivation, or emotional resilience
• Improve social ease or positive inner dialogue
• General curiosity or spiritual exploration without major issues

→ Likely candidate for self-managed conservative Minordose Protocol.

B – Mood & Life Enhancement
(Still often self-manageable, but add coaching/therapy for best results)

• Mild-to-moderate ongoing anxiety or low-grade depression
• Stuck patterns, procrastination, or lack of life direction
• Desire for deeper self-acceptance or forgiveness work

→ Start with Minordose Protocol + journaling; strongly consider an integration coach or therapist.

C – Deeper Healing or Mental Health Support
(Professional guidance strongly recommended or required)

• PTSD, complex trauma, or childhood wounding
• Moderate-to-severe depression or treatment-resistant anxiety
• Addiction recovery support (beyond early sobriety)
• Major life transitions or existential crisis

→ Do not attempt alone. Seek psychedelic-assisted therapy, a trained facilitator, or legal clinical program where available. Minor dosing can be an adjunct, but only under guidance.

D – Clinical/Therapeutic Treatment
(Only in legal, supervised settings)

• Diagnosed condition being treated in a formal psilocybin therapy program
• Working directly with licensed clinicians or in an approved trial

→ Follow the medical/facilitated protocol only.

Final Decision Tree

• Part 1 has any YES → Abstain completely
• Part 1 clear + Goal A → Safe to begin conservative self-managed Minordose Protocol
• Part 1 clear + Goal B → Begin Minordose Protocol + add coaching/therapy
• Part 1 clear + Goal C or D → Seek professional psychedelic-assisted therapy; do not self-administer macro doses

Take your time with this assessment. Your safety and long-term well-being are far more important than any experience. When in doubt, err on the side of caution and get professional input.